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Cyclophilin Inhibitor Fast Tracked for Nonalcoholic Steatohepatitis > 2021 > November

Month: November 2021

Cyclophilin Inhibitor Fast Tracked for Nonalcoholic Steatohepatitis

Steve Duffy November 30, 2021

The Food and Drug Administration (FDA) has granted Fast Track designation to CRV431 for the treatment of nonalcoholic steatohepatitis (NASH). CRV431 works by specifically binding to cyclophilin isomerase enzymes and inhibiting cyclophilin function with high…

FDA Rejects Pedmark NDA Again Citing Manufacturing Deficiencies

Steve Duffy November 30, 2021

The Food and Drug Administration (FDA) has issued a second Complete Response Letter (CRL) to Fennec Pharmaceuticals regarding the New Drug Application (NDA) for Pedmark (sodium thiosulfate) for the prevention of ototoxicity associated with cisplatin…

Red Blood Cell Exchange Transfusion May Be Beneficial in Patients With Sickle Cell Disease and COVID-19

Top-Meds November 30, 2021

According to a case study published in Clinical Case Reports, red blood cell exchange transfusion (RBCX) appears be beneficial in patients with sickle cell disease and COVID-19. The authors propose prophylactic RBCX prior to respiratory…

Are Adult Men at Increased Risk for Myocarditis After COVID-19 mRNA Vaccination?

Top-Meds November 30, 2021

A retrospective case-series study found that although a rare adverse event, myocarditis occurred more among adult men who received an mRNA-based COVID-19 vaccination than among the background population. The findings were published in Clinical Infectious…

Signs of Autism Spectrum Disorder Appear as Early as Infancy

Top-Meds November 30, 2021

Infants who later developed autism spectrum disorder (ASD) were found to observe objects more closely and more frequently than infants who did not develop ASD, according to a recent study. This behavior was found to…

Mango Peels Offer Potential Benefit in Overweight and Obesity Disorders

Top-Meds November 30, 2021

Antioxidants such as caffeic acid, gallic acid, chlorogenic acid, kaempherol, and vitamin C found in mango peels may help in the management of dyslipidemia and oxidative stress in people with overweight and obesity disorders, according…

More Reasons to Avoid ‘Beyond’ Fake Meat

Dr. Mercola November 30, 2021

This article was previously published October 7, 2020, and has been updated with new information. Beyond Meat is one of a handful of companies flooding the market with plant-based burgers and other fake meat products,…

mRNA Vaccines Put You at Risk for Acute Coronary Syndrome

Dr. Mercola November 30, 2021

In a November 21, 2021, tweet, cardiologist Dr. Aseem Malhotra writes:1 “Extraordinary, disturbing, upsetting. We now have evidence of a plausible biological mechanism of how mRNA vaccine may be contributing to increased cardiac events. The…

Sudden Surge in Stillbirths and Menstrual Changes

Dr. Mercola November 30, 2021

November 11, 2021, a rally formed outside of Lions Gate Hospital in North Vancouver, British Columbia (BC). The group was there to call attention to an unthinkable tragedy: 13 babies were reportedly stillborn at the…

Deucravacitinib Under Review for Moderate to Severe Plaque Psoriasis

Steve Duffy November 29, 2021

The Food and Drug Administration (FDA) has accepted for review the New Drug Application for deucravacitinib, a selective tyrosine kinase 2 (TYK2) inhibitor, for the treatment of adults with moderate to severe plaque psoriasis. The…

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